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The evidence base combines animal models showing dramatic retinal preservation, early-stage human trials demonstrating measurable improvements in visual function tests, and mechanistic studies explaining how specific peptides interact with retinal cells and vascular structures

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from an independent Chinese research group (PMID: 34827486) demonstrated that Dihexa rescued cognitive impairment in APP/PS1 Alzheimer's disease model mice via the PI3K/AKT signaling pathway, providing the first independent replication of cognitive enhancement effects